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Major General Horatio G. Wright issued General Orders No. 1 on August 23, 1862, taking command of the Department of the Ohio.

On March 18, 1864, Major General William T. Sherman issued General Orders No. 1 taking command of the Division of the Mississippi.

On July 27, 1861, Major General George B. McClellan issued General Orders, No. 1 (Division of the Potomac) announcing that he was assuming command of the Division of the Potomac.

On January 10, 1863, Major General Franz Sigel issued General Orders, No. 1 (Grand Reserve Division, Army of the Potomac), assuming command of the Grand Reserve Division, Army of the Potomac.

On February 9, 1865, Robert E. Lee issued General Orders, No. 1 (CSA) announcing that he had assumed command of the military forces of the Confederate States.

On January 1, 1864, the U.S. War Department issued General Orders, No. 1 assigning Samuel R. Curtis to command the re-created Department of Kansas.

On January 7, 1865, the U.S. War Department issued General Orders, No. 1, announcing that President Abraham Lincoln had relieved Benjamin Butler of command of the Department of North Carolina.

On April 23, 1861, Major General Robert E. Lee issued General Orders, No.1 announcing that he was assuming command of the military and naval forces of Virginia.

On March 29, 1862, Confederate General Albert Sidney Johnston issued eight general orders in one document, reorganizing the troops under his command in the Western Military Department.

On March 13, 1862, Major General George B. McClellan issued General Order No. 101, reorganizing the Army of the Potomac into five corps, in compliance with president Abraham Lincoln's War Order No. 2.

On August 11, 1862, the US War Department issued General Orders, No. 101, announcing President Abraham Lincoln's appointment of Major General Henry Halleck as General-in-Chief of US land forces, effective July 11, 1862.

On August 12, 1862, the U.S. War Department issued General Orders No. 103, codifying President Abraham Lincoln's June 26 order to create the Army of Virginia, Major General John Pope commanding.

On August 13, 1862, the U.S. War Department issued General Orders, No. 104, announcing President Abraham Lincoln's executive order prohibiting citizens liable for the draft from leaving the United States, and suspending the writ of habeas corpus for persons arrested for disloyal practices.

On December 5, 1861, the Headquarters of the US Army issued General Orders, No. 106, announcing appointments to fill the ranks of officers. This is a partial transcript of the order listing appointments to the ranks of major general and brigadier general.

On August 16, 1862, the U.S. War Department issued General Orders, No. 109 announcing that President Abraham Lincoln authorized military commanders to seize property in states in rebellion for military purposes. The order also authorized military leaders to employ laborers of African descent for military purposes.

On May 9, 1862, Major General David Hunter, commanding the Department of the South, issued General Orders, No. 11, declaring the slaves in Georgia, South Carolina, and Florida to be forever free.

On January 30, 1865, the U.S. War Department issued General Orders, No. 11, merging the Department of Kansas into the Department of the Missouri, naming John Pope to command the Division of the Missouri, including the Departments of the Missouri and the Northwest, and transferring Samuel R. Curtis to the Department of the Northwest.

On December 24, 1862, Confederate President Jefferson Davis issued General Order, No. 111 (CSA) designating Major General Benjamin Butler and all officers serving under him as "as robbers and criminals deserving death." Davis' order also stated that "That all negro slaves captured in arms be at once delivered over to the executive authorities of the respective States to which they belong to be dealt with according to the laws of said States."

Issued by the U.S. War Department on August 19, 1862, War Orders Number 112, re-created the Department of the Ohio, with Major-General Horatio G. Wright in command.

On March 23, 1864, the U.S. War Department issued General Orders, No. 115 announcing the reorganization of the Army of the Potomac as ordered by President Abraham Lincoln.